Product Description

Xifaxanta 200 mg film-coated tablets can be used to treat moderate severity traveller´s diarrhoea in adults when the diarrhoea is not accompanied by:

  • Fever
  • Blood in the stools
  • 8 or more unformed (soft or liquid) stools in the last 24 hours.

Xifaxanta 200 mg film-coated tablets are not recommended for use in children (aged less than 18 years).

Travellers' diarrhoea is common throughout the world but some areas present greater risk than others.  The risk of suffering a bout is often higher in Africa, Asia and South America; certainly higher than the risk through Europe and North America.  Typical causes include E. coli and Campylobacter species of bacteria, but other tropical organisms are often involved.   

Xifaxanta is known as an intestinal antibiotic, which makes it ideal for treating infections that live within the gut.  Intestinal antibiotics are not absorbed into the body, which makes them a safe choice for treating moderate-severity diarrhoea, but a poor choice if the infection is invasive, which is why you must seek medical attention if you have:

  • Fever
  • Blood in the stools
  • 8 or more unformed (soft or liquid) stools in the last 24 hours.

Xifaxanta 200mg tablets are manufactured by Norgine.


Xifaxanta tablets should be taken when moderate-severity diarrhoea has started.  The dose is one tablet three times a day for 3 days.  The full course should always be taken even if symptoms start to improve.  

If symptoms do not improve after 3 days please seek medical attention.  

Xifaxanta should be swallowed whole with a glass of water.  Do not crush the tablet.





Xifaxanta tablets contain the following ingredients:

Active: Rifaximin 200mg

In addition to the active ingredient the tablet often contains the following inactive ingredients:

Tablet core: Sodium starch glycolate type A, glycerol stearate, colloidal anhydrous silica, talc, microcrystalline cellulose

Tablet coat: hypromellose, titanium dioxide (E171), disodium edetate, propylene glycol, red iron oxide (E172)


This list is not exhaustive, please read the product information leaflet

Side Effects

The following side effects are known to occur when using Xifaxanta:

Common (may affect up to 1 in 10 people):

  • headache
  • wind, abdominal bloating, abdominal pain, constipation, diarrhoea, the urgency to empty your bowels, nausea, involuntary and painful or ineffective straining, vomiting
  • fever

Uncommon (may affect up to 1 in 100 people):

  • thrush, cold sore, inflammation, or infection of the nose and throat
  • abnormal test results in white blood cells
  • loss of appetite, loss of body fluid (dehydration)
  • abnormal dreams, depressed mood, sleeplessness, nervousness
  • numbness, migraine, pins and needles, sinus headache, drowsiness
  • double vision
  • earache, the sensation of the room going round (vertigo)
  • increased blood pressure,
  • hot flushes
  • cough, dry throat, blocked nose, sore throat, runny nose
  • upper abdominal pain, indigestion, intestinal movement disorder, dry lips, hard stools, blood in the stools, mucus in stools, taste disorders
  • blood test results: increased liver enzyme values
  • sunburn
  • back pain, muscle cramps, muscle weakness, muscle pain, neck pain
  • abnormal urine test results: blood in urine, protein in urine, sugar in urine,
  • frequent urination, excessive urination
  • frequent periods
  • chills, cold sweat, increased sweating, flu-like illness, and pain

For a full comprehensive list of all known side effects please read the patient information leaflet.



Do not take Xifaxanta 200 mg film-coated tablets if you are allergic (hypersensitive) to rifaximin, to similar types of antibiotics (such as rifampicin or rifabutin), or to any of the other ingredients of this medicine

As mentioned previously do not use Xifaxanta if:

  • you have a fever;
  • if you have blood in your stools;
  • if you passed 8 or more unformed stools in the last 24 hours.
  • if you have constipation, abdominal pain, and vomiting caused by blockage of the bowel

Taking this medicine may cause a reddish discoloration of your urine.

Drug Interactions

Xifaxanta has limited drug interactions but important interactions include:

  • Activated Charcoal.  Xifaxanta should be taken at least 2 hrs after charcoal
  • Warfarin
  • Ciclosporin

Pregnancy and Breastfeeding

Xifaxanta is not recommended for use during pregnancy or for fertile female patients not using effective contraception. 

Due to limited safety data, Xifaxanta should not be used whilst breastfeeding.




Patient Information Leaflet

To view or download this medicine patient information leaflet (PIL) please Click Here

Frequently Asked Questions

How do I take this medicine?

Xifaxanta 200 mg film-coated tablets can be taken with or without food and should be swallowed with a glass of water. You should not break or crush these tablets.

Unless prescribed otherwise, the usual dose is 1 tablet every 8 hours (600 mg/day). You should continue taking Xifaxanta 200 mg film-coated tablets for three days even if your symptoms have improved. In most cases, the duration of the treatment should not exceed three days. If your symptoms persist for more than three days please see a doctor.

Taking this medicine may cause a reddish discolouration of your urine


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